Pathogen-induced inflammation includes a molecular pathway which proceeds through activation of the protease caspase-1 to the release of the inflammatory cytokines interleukin-1 (IL-1) and IL-18.

These proteases typically lie dormant in the healthy ... Initiator caspases (such as caspase 8 and caspase 9) activate the effector caspases and have long prodomains that allow them to interact ...

This focus has evolved to include the investigation of non-apoptotic functions of proteins that have long been considered to have roles in apoptosis, the caspase family of proteases. Our research ...