Prion diseases are characterized by abnormal folding of the host’s naturally-occurring prion protein, leading to rapid neurodegeneration. They can be genetic, sporadic—without known cause—or acquired, ...

Almost two decades have passed since Stanley Prusiner proposed that the transmissible agent causing spongiform encephalopathies consists of a misfolded protein — but the biology of prion ...

The findings are published in the journal BMC Cancer. In the study, the team discovered that the prion protein plays a key role in the biology of glioblastoma. "The treatment of glioblastoma has ...

The findings provide further evidence for a prion-like paradigm wherein protein aggregation occurs in a templated ... RNA ...

The aggregation can be caused by chance; by protein hyperphosphorylation (a condition where multiple phosphate groups are added to the protein), by prion self-catalytic conformational conversion ...

May 17, 2024 — A new study of prion diseases, using a human cerebral organoid model, suggests there is a substantial species barrier preventing transmission of chronic wasting disease (CWD ...