Using an elegant and thorough experimental design, Thomazeau et al show that, in the developing mouse visual cortex, presynaptic NMDA receptors at layer 5 neocortical synapses mediate spike-timing ...

The results offer compelling evidence that L5-L5 tLTD depends on presynaptic NMDARs, a concept that has previously been somewhat controversial. It documents the novel finding that presynaptic NMDARs ...

Experience-dependent glial synapse pruning plays a pivotal role in sculpting brain circuit connectivity during early-life critical periods of development. Recent advances suggest a layered cascade of ...

Estrogens (green hexagons) synthesized within the presynaptic bouton are then available to bind presynaptic ERs (gray ovals) and modulate the dynamics of presynaptic neurotransmitter release.