This study explores the use of polarized second-harmonic generation (pSHG) to investigate myosin conformation in the relaxed state, differentiating between the actin-available, disordered (ON) state ...

Researchers have developed MiROM, a new infrared-based microscopy tool that detects protein misfolding in single cancer cells ...

Discover what glycan analysis can reveal about protein behavior and how it can be used to boost biologic performance and ...

Accurate extraction of molecular representations is a critical step in the drug discovery process. In recent years, significant progress has been made in molecular representation learning methods, ...

Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

Molecular structure of tuberculosis efflux pump reveals how bacteria resist key antibiotic by Jeff Hansen, University of Alabama at Birmingham ...

In a study published in Cell Research, a research team has, for the first time, resolved the high-resolution in situ structure of the central apparatus (CA) within the axoneme of mammalian sperm.

Nicolás Maduro's regime has transformed Venezuela into an international criminal organization, using state institutions for internal repression, looting national resources and collaboration with ...

Researchers made small tweaks to the molecular structure of LSD to see if it could be turned into an effective brain-healing treatment.

To address these issues, we propose a novel multi-relation DGI prediction method based on molecular structure-driving and high-low-order attention denoising framework. Our approach captures molecular ...

A new discovery about the slime ejected by velvet worms could revolutionize sustainable material design. The findings outline how a naturally occurring protein structure, conserved across species ...