Next, I’d like to address the issue of atypical neurofibromas and their potential to become malignant peripheral nerve sheath tumors (MPNST), probably the most feared complication of NF1. Occurring in ...

Peripheral nerve sheath tumors (PNSTs), particularly schwannomas, are the most common type of nerve tumors. These tumors arise from the protective sheath surrounding peripheral nerves and can ...

Among the peripheral nerve sheath tumors (PNSTs) evaluated, which included 20 MPNSTs and two neurofibromas, only 9% showed reactivity for pan-cytokeratin, 18% for CK7, and none for CK19. [These ...

A combination of two cancer drugs could be effective against malignant peripheral nerve sheath tumors (MPNSTs) - soft tissue tumors that are stubbornly resistant to chemotherapy and radiation ...

The focus of this month’s blog post is a discussion of malignant peripheral nerve sheath tumors (MPNSTs), which represent one of the few potentially life-threatening complications of neurofibromatosis ...

Undifferentiated pleomorphic sarcomas, myxofibrosarcomas, and malignant peripheral nerve sheath tumors are characterized by complex genomic characteristics and aggressive clinical behavior. Recent ...

A new mini review was published in Oncotarget's Volume 15 on September 30, 2024, entitled, "Linking FOXM1 and PD-L1 to CDK4/6-MEK targeted therapy resistance in malignant peripheral nerve sheath ...

Bin Liu, Wang Xin, Jian-Rong Tan, Rui-Ping Zhu, Ting Li, Dan Wang, Sha-Sha Kan, Ding-Kui Xiong, Huan-Huan Li, Meng-Meng Zhang, Huan-Huan Sun, William Wagstaff, Chan Zhou, Zhi-Jian Wang, Yao-Guang ...

Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor. Molecular Cancer Therapeutics, 2023; 22 ...

"We are excited to see complete responses in a murine model of malignant peripheral nerve sheath tumors, an effect that no small molecule drug before INT230-6 has achieved in our lab before," said ...

Researchers from Johns Hopkins University and affiliated organizations have published details on the discovery and preclinical characterization of a purine antimetabolite, Pro-905, which is being ...