The nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels, the activity of which modulates many neurotransmitter systems. They are therefore therapeutic targets for the ...

Objective Electronic nicotine delivery systems (ENDS), such as e-cigarettes, have surged in popularity. While long-term risks remain unclear, known dangers include nicotine addiction, E-cigarette or ...

Background: Varenicline, a new treatment for smoking cessation, has demonstrated significantly greater efficacy over placebo and sustained release bupropion (bupropion SR). A study was undertaken to ...

Varenicline is completely absorbed orally and not affected by food. Steady state is reached within four days of administration. The time to reach maximum concentration is three to four hours.

Over the last several decades, the global incidence and prevalence of diabetes mellitus has increased significantly. The raised incidence rate is projected to continue as greater numbers of persons ...

Coordinated smoking cessation interventions that combine nonpharmacological and pharmacological approaches can increase cessation rates by 2 to 3 times that of self-quit attempts.10An RCT of a ...

Medicines including nicotine replacement therapy (gums, patches, etc.), varenicline, bupropion, and cytisine could be used to stop vaping. These are already used to help people stop smoking.

Varenicline and bupropion prescribing was very low, and less common in those with SMI. There were temporal trends in recorded smoking cessation interventions in primary care. We observed a steep ...

Two existing medications—one used for smoking cessation and the other for depression—appear to work effectively together in treating alcohol use disorder. The combination reduces alcohol ...

Two existing medications—one used for smoking cessation and the other for depression—appear to work effectively together in treating alcohol use disorder. The combination reduces alcohol cravings, ...