Rolling Out8d
Tiny cell structure holds key to aging process
Scientists uncover how the nucleolus, a tiny structure within cells, may control aging and lifespan, opening new ...
Architects' Journal28d
5th Studio launches retrofit pattern book
The book, which looks specifically at flat-fronted Victorian terraced house types, is the first in a proposed series of downloadable documents which will eventually cover almost all of the UK’s ...
Frontiers1mon
Identification of nuclear valosin-containing-protein-like as a target of anti-nuclear autoantibodies in systemic sclerosis
Results: The index patient serum displayed a homogeneous nucleolar staining pattern on HEp-2 cells and monkey liver by IFA but did not react with 27 known nuclear antigens. Nuclear ...
eLife4y
Cross-compartment signal propagation in the mitotic exit network
Once in the nucleus, priming phosphorylation of Cfi1/Net1, the nucleolar anchor of Cdc14, by the Polo-like kinase Cdc5 targets Dbf2-Mob1 to the nucleolus. Nucleolar Dbf2-Mob1 then phosphorylates ...
insights.omnia-health5y
Multiplex autoantibody diagnostics in systemic sclerosis
In IIFT, SSc-associated autoantibodies give rise to various fluorescence patterns, for example nucleolar (eg. anti-Scl-70, anti-PM-Scl100, anti-PM-Scl75, anti-RP11, anti-RP155, anti-Th/To, anti-NOR90, ...
Frontiers5y
Nucleolar Sequestration: Remodeling Nucleoli Into Amyloid Bodies
This year marks the 20th anniversary of the discovery that the nucleolus can temporarily immobilize proteins, a process known as nucleolar sequestration. This review reflects on the progress made to ...