Researchers report that eight healthy babies were born with the help of an experimental technique that uses DNA from three ...

When environmental stress harms DNA, it can set off a cascade of failures linked to heart conditions, neurodegeneration, and ...

This groundbreaking technique aims to prevent children from inheriting severe, incurable mitochondrial diseases from their ...

Approximately one in 5,000 children is born with mitochondrial mutations each year. Defective mitochondria "leave the body ...

Researchers have designed a chemical probe to bind damaged mitochondrial DNA, halting the enzymatic processes that lead to ...

Few off-target edits appeared in the nuclear DNA, and only a small number occurred elsewhere in mitochondrial DNA. This precision reduces the risk of accidental damage that could lead to cancer or ...

Now, scientists at the University of California, Riverside, may have found a way to halt the damage before it begins. The ...

Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts. PLOS Biology, 2024; 22 (8): e3002723 DOI: 10.1371/journal.pbio.3002723 ...

More information: Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts, PLoS Biology (2024). On bioRxiv: DOI: 10.1101/2023.02.03.527065 ...

The story of this potentially paradigmatic development begins where so much of human health begins: the mitochondria.

Mitochondria release segments of mitochondrial DNA that can travel through pores of the nucleus and integrate into a cell's chromosomes (where the insertions are called NUMTs, for nuclear ...

Somatic nuclear mitochondrial DNA (Numt) insertions are mito-nuclear gene transfer events that can arise in the germline and in cancer. This study shows that Numt insertions arise spontaneously ...