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C&EN1d
Proteome-Wide Characterization of the RNA-Binding Protein RALY-Interactome Using the in Vivo-Biotinylation-Pulldown-Quant (iBioPQ) Approach
Here, we present a workflow for the characterization of RALY’s interaction partners, termed iBioPQ, that involves in vivo biotinylation of biotin acceptor peptide (BAP)-fused protein in the presence ...
C&EN2d
Spontaneous Isomerization of Long-Lived Proteins Provides a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer’s Disease
Department of Chemistry, University of California, Riverside, California 92521, United States Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF ...
IFLScience5d
Nearly 50 Years After An Infected Injection, Prions Rapidly Take Over A Woman's Brain
A fter silently lurking for almost 50 years, a prion disease erupted in the brain of a woman in the US, triggering a rapid ...
Nature5d
Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells
Figure 1: FACS analysis of spleen cells from BM-grafted uninfected mice, stained with PrP-specific antibody (open histograms) or unstained (shaded histograms). Figure 2: Confocal analysis of ...
Understanding how Creutzfeldt-Jakob disease hides in neurons for decades
In April 2025, three people in Oregon developed Creutzfeldt-Jakob disease (CJD), a rare, fatal neurological condition that is ...
Nature6d
Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease
Amyloid β protein (Aβ) deposition in the brain is a hallmark of Alzheimer's disease (AD). The fibrillar form of Aβ is neurotoxic, although the mechanism of its toxicity is unknown. We showed ...