and acetylcholine receptor antibody (AChR-Ab; orange triangles) from baseline during cycle 1 of the ADAPT trial of efgartigimod (at a dose of 10 mg per kilogram of body weight per week for 4 weeks ...

The results demonstrated durable and sustained efficacy of UPLIZNA in patients with acetylcholine receptor autoantibody-positive (AChR+ ... of Myasthenia Gravis Activities of Daily Living (MG-ADL) ...

Whalen Veterans Affair Medical Center, Salt Lake City, Utah 84148, United States Nicotinic acetylcholine receptors containing ... To assess the necessity of T-cells in the mechanism of action of ...

We show baseline differences between adult and adolescent-stimulated dopamine release in male rats, as well as opposite effects of the α6 nicotinic acetylcholine receptor (nAChR ... herein suggest a ...

This mechanism ... 7 nicotinic acetylcholine receptors (nAChRs). Activating ⍺7 nAChRs with agonists or stimulating endogenous acetylcholine inhibited vlPAG neuronal activity through Ca 2+ and ...

It was inferred that incubation at 37°C for 24 hours was sufficient to detect the binding of the peptides to the human nicotinic acetylcholine receptor (a7-AChR). Additionally, a7-AChR also bound ...

Acetylcholine (ACh), released ... This effect is mimicked by a selective antagonist of nicotinic AChRs delivered in CA2. Ex vivo recordings from hippocampal slices provide insight into the underlying ...

and thus suggest temporal control of nAchR subunits as a key regulatory mechanism underlying the development and activity-dependent plasticity in central cholinergic synapses.

The α7 nicotinic acetylcholine receptor (α7nAChR ... essential regulator of inflammation as this receptor mediates the inhibition of cytokine synthesis through the cholinergic anti-inflammatory ...

Finally, we locate binding of the drug PNU-120596 (PNU) and propose a mechanism for α7 modulation in which PNU displacement of cholesterol promotes opening versus desensitizing. The α7 nicotinic ...