This research will provide valuable insights into our understanding of mechanisms of addiction ... with the upregulation of nicotinic acetylcholine receptors (nAChRs), a critical indicator of ...

Nicotine molecules bind to the body’s nicotinic acetylcholine receptors, which are involved ... One cigarette can contain 10 to 15 mg of nicotine. A piece of nicotine gum often has much less ...

Interestingly, it was recently shown that different microglial phenotypes are associated with distinct metabolic pathways and analysis of the underlying molecular mechanisms ... Alpha-7 nicotinic ...

Striatal dopamine (DA) release regulates reward-related learning and behavioural activation and is believed to consist of a short-lived phasic and continuous tonic component. Here, we build a ...

“Glucagon-Like Peptide-1 Receptor: Mechanisms and Advances in Therapy.” Signal Transduction Targeted Ther. (Sept. 2024). DOI: 10.1038/s41392-024-01931-z. A collaboration between C&EN and Andy ...

The discovery and development of GLP-1 receptor agonists for type 2 diabetes and obesity is a bench-to-bedside success story.1 Multiple GLP-1 receptor agonists are now in clinical use, such as ...

We strive to develop medications that do only 1 or 2 things (ie, blocking serotonin reuptake or blocking D2 and 5HT2a receptors) and do nothing else. We assume that all other mechanisms of action ...

According to the World Health Organization (WHO), over 22% of the global population smokes, with more than 9 million smoking-related deaths reported annually. Effective treatments to alleviate ...

M2 receptors, located on the postganglion endings of the cholinergic fibers, with the role of limiting further acetylcholine release from the postganglion endings; and M3 receptors, located on the ...