Recent research shows that the mechanism of action of ketamine is complicated but involves the opioid receptors of the brain.

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After turning down Takeda's Fruzaqla for metastatic colorectal cancer (mCRC) in draft guidance last year, NICE has changed its mind and recommended the drug for use by the NHS in England and Wales.

He also claimed that NICE's appraisal process "is simply not fit to evaluate medicines for early Alzheimer’s" and – given that there are dozens of drugs coming through the industry pipeline ...