Autism spectrum disorders (ASDs) are neurodevelopmental disorders caused by various genetic and environmental factors that result in synaptic abnormalities. ASD development is suggested to involve ...

Researchers in the United States and Sweden have created personalized models of fetal brain microglia to investigate the effects of maternal infection on the developing brain, including infection ...

Heavy prenatal alcohol exposure is associated with neurodevelopmental abnormalities. Neuropathologic and neuroimaging studies have shown a wide range of structural problems, including abnormal ...

Oct. 17, 2023 — Schizophrenia, a neurodevelopmental disorder that features psychosis among its symptoms, is thought to arise from disorganization in brain connectivity and functional integration ...

This could contribute to CYFIP1-related neurodevelopmental and psychiatric disorders resulting in part from microglia dysfunction. Among the specific disorders linked to variation in CYFIP1 are ...

More information: Kazuya Fuma et al, Prenatal inflammation impairs early CD11c-positive microglia induction and delays myelination in neurodevelopmental disorders, Communications Biology (2025 ...

A growing body of research suggests that neurobiological changes, particularly abnormalities in dendritic spines, tiny protrusions on nerve cells where synapses form, may be a hallmark of ASD.

Microglia are shown in red, and CD11c-positive cells in green. Scale bar = 100 µm. A research group led by Nagoya University Graduate School of Medicine in Japan has uncovered a potential ...

Furthermore, immune abnormalities are accompanied by abnormalities in the intestinal microbiota, which is also thought to be involved in the pathogenesis of the disease via the brain-gut axis.

New genetic variants associated with balanced alterations of chromosome structure have been identified in individuals with autism and related neurodevelopmental disorders, many of which are also ...

Two distinct neurodevelopmental abnormalities that arise just weeks after the start of brain development have been associated with the emergence of autism spectrum disorder, according to a new ...