"It is with extremely heavy hearts that we share the loss of our beautiful Natalie this morning from colon cancer," her family wrote. She was 53. "She was a bright light in this world. A queen.

Born Aug. 4, 2004, Natalie is the oldest child of the president's late son, Beau, who passed away from brain cancer in 2015. She has one brother, Robert Hunter Biden III, who is two years younger.