is an NMDA receptor blocker. More information: Sergio Escamilla et al, Synaptic and extrasynaptic distribution of NMDA receptors in the cortex of Alzheimer's disease patients, Alzheimer's ...

A 3D model of the NMDA receptor was created to help researchers predict where ketamine would bind. “The simulations show that at high concentrations, which is how it is used as an anesthetic ...

Scientists have created a new therapeutic approach for testing fragile X syndrome, which is the most common genetic cause of ...

Fragile X syndrome is the most common genetically-caused autism spectrum disorder. It causes a range of developmental issues, ...

This work shows that enhancing the function of the GluN2b subunit of the N-methyl-D-aspartate (NMDA) receptor signaling pathway can correct key neural dysfunctions in a mouse model of fragile X ...

Ketamine has received a Hollywood makeover. It used to be known as a rave drug (street name special K) and cat anesthetic. However, in recent years, some doctors have prescribed ketamine to treat ...

Blocking NMDA receptor activity abolished LTP-mediated inhibition of LTD, showing that transient activation of NMDA receptors mediates this effect. To investigate the downstream signalling ...

Building on more than two decades of research, a study by MIT neuroscientists at The Picower Institute for Learning and ...

NMDAR = N-methyl-D-aspartate receptor; VGKC = voltage-gated potassium channel a In some patients with paraneoplastic anti-NMDAR encephalitis, the possibilities of bacterial infections, HIV ...

It has long been understood from their seminal work in the 1990s that the flow of calcium ions through NMDA receptor can trigger a form of synaptic plasticity called “long-term depression” (LTD).