All of these drugs act at the mu-opioid receptor, which is responsible for their pain relieving properties as well as their addictive and lethal properties. University of Michigan basic science ...

Distinct brain circuits drive two key components of addiction to the synthetic opioid drug fentanyl, according to a new finding published in Nature (2024, DOI: 10.1038/s41586-024-07440-x).

They’re the only opioid receptor that doesn’t cause respiratory depression. They can also have an anti-reward, dysphoric effect, which is the opposite effect of mu receptors. So, while they do ...

Intermediate efficacy mu opioid receptor (MOR) agonists have potential to retain analgesic effectiveness while improving safety, but the optimal MOR efficacy for effective and safe opioid analgesia is ...

By Jan Hoffman Jan Hoffman has been reporting on the national opioid litigation since 2017. After years of litigation to hold the pharmaceutical industry accountable for the deadly abuse of ...

Researchers have been racing to develop safer pain reliever drugs that target a specific opioid receptor, called the kappa opioid receptor, that is only found in the central nervous system and not ...

The main ones are mu, kappa, and delta. Partial opioid agonists can act on any opioid receptor. Unlike a full agonist, which can cue a cell to produce the maximum opioid effect, partial agonists ...

The "MU" in MU-MAN plays on Relistor's mechanism of action, which works as a mu-opioid receptor antagonist. In the 60-second ad, MU-MAN’s obstinate mood changes and relief is felt once the ...

Professor Anne Roivainen from the Turku PET Centre tells that this is the first time mu-opioid receptor levels have been assessed in peripheral regions using positron emission tomography (PET ...

Fentanyl, a mu-opioid receptor agonist, is one of the most commonly used analgesics in hospitals, and may induce long-lasting behavioral and somatosensory impairment in rodents. However ...

A schematic diagram describing major signaling abnormalities associated ... to be an effective alternative therapy to the standard anti-dyskinetic therapy. Mu-delta opioid receptor agonism can also be ...