The direct comparison of mice lacking each of the three opioid-receptor genes reveals that mu- and delta-opioid receptors act oppositely in regulating emotional reactivity. This highlights a novel ...

New findings show that heavy drinkers with the G allele of the A118G polymorphism of the mu-opioid receptor gene have greater cravings after alcohol exposure than heavy drinkers homozygous for the ...

Those attempts were doomed to failure because all opioid drugs interact with the brain in the same way. They dock to a specific neural receptor, the mu-opioid receptor, which controls the effects ...

3 Wang et al. found that GPR139, a poorly understood GPCR, 4 interacts with the mu opioid receptor and acts as a brake to oppose the effects of opioid drugs. Blocking GPR139 would therefore be ...

Fentanyl, a mu-opioid receptor agonist, is one of the most commonly used analgesics in hospitals, and may induce long-lasting behavioral and somatosensory impairment in rodents. However ...

Naloxone is a competitive antagonist at the mu-opioid receptor. It is thought to reduce the intensity of itching through antagonism of the mu-opioid receptor both centrally and peripherally ...

Previous research showed that mice lacking the mu opioid receptor do not drink alcohol. A new study shows that mice lacking the delta opioid receptor drink more alcohol. The delta opioid receptor ...

For their study, the researchers combined the structural information of the mu-opioid receptor with a computational technique called “molecular docking.” This allowed the team to conduct ...

Professor Anne Roivainen from the Turku PET Centre tells that this is the first time mu-opioid receptor levels have been assessed in peripheral regions using positron emission tomography (PET ...

New findings show that heavy drinkers with the G allele of the A118G polymorphism of the mu-opioid receptor gene have greater cravings after alcohol exposure than heavy drinkers homozygous for the ...