During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.

Researchers have found in a new study that CCR2 shows strong potential as a biomarker for diseased aortic tissue in abdominal ...

ImmuneWalk Therapeutics has presented positive topline data from the single ascending dose (SAD) part of the randomised, ...

Pharmacodynamics provides mechanistic validation, demonstrating dose-dependent binding of IW-601 to myeloid cells (monocytes ...

Fluorescent reporter lines (eg, GFP-CD68 [green fluorescent protein CD68], CX3CR1-GFP [CX3C chemokine receptor 1 green fluorescent protein]) and congenic mice (eg, CD45.1, CD45.2) also allow for ...

Background Current treatments with tyrosine kinase inhibitors and immune checkpoint inhibitors have limited efficacy for ...

Repurposing existing therapies may help slow muscle weakness in patients with Duchenne muscular dystrophy, a new study ...

A prospective study of sex hormone use in patients seeking transgender treatments suggests how these hormones may influence kidney health.

Conclusion Our study reveals a critical role for monocyte-derived MΦs in restoring intestinal homeostasis after surgical trauma. From a therapeutic point of view, our data indicate that inappropriate ...

Demographic characteristics, clinical presentations, and hematological indices including the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio ...