According to a new study published in the journal Cellular Signalling, cannabinoids may play a crucial role in preventing and treating brain diseases by regulating key physiological processes in the ...

One of these is neuroinflammation. That's what we looked at in our studies. Specifically, we pharmacologically manipulated a molecular complex called the NLRP3 inflammasome. It is found in ...

The current results support this approach. “It is known that inhibiting NLRP3 not only reduces neuroinflammation, but also helps microglia clear the harmful amyloid-beta deposits, a process ...

Graphical Abstract. Hypothetical mechanisms of mitophagy dysfunction in POLG-mutant astrocytes. Nicotinamide riboside was provided by Evandro Fei Fang (University of Oslo, Norway). The cells were ...

State Key Laboratory of Crystal Materials, Department of Otolaryngology-Head and Neck Surgery, Shandong Institute of Otorhinolaryngology, Shandong Provincial ENT Hospital, Shandong University, Jinan, ...

for diseases associated with neuroinflammation. The Company has nominated a member of this class, the orally available, small-molecule brain-penetrant NLRP3 inhibitor BGE-102, as a development ...

Background: The neuroinflammation triggered by acute cerebral ischemia can be mediated through inflammasome such as NLRP3 (NOD-like receptor family, pyrin domain containing 3) and ASC ...

1 Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, United States 2 Laboratory of Molecular Virology, School of Systems Biology, George Mason University, ...

The company’s pipeline includes novel, orally available, brain-penetrant small-molecule NLRP3 inhibitors to treat metabolic diseases and conditions driven by neuroinflammation, as well as novel, ...

The company's pipeline includes novel, orally available, brain-penetrant small-molecule NLRP3 inhibitors to treat metabolic diseases and conditions driven by neuroinflammation, as well as novel ...