Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

Pembrolizumab (Keytruda), an anti-PD-1 antibody, cleared minimal residual disease and protected against recurrence in patients with DNA mismatch repair-deficient (dMMR) early-stage solid cancers ...

Dostarlimab effectively eliminates the need for surgery in patients with advanced mismatch repair–deficient ... dMMR refers to a malfunction in the DNA repair mechanism, which causes errors ...

However, the mechanistic connections between mismatch DNA repair and selective neuronal vulnerability in Huntington’s disease remain unknown. The new study from UCLA Health and the Jane and ...

However, the mechanistic connections between mismatch DNA repair and selective neuronal vulnerability in Huntington's disease remained unknown. The new study from UCLA Health and Jane and Terry ...

However, the mechanistic connections between mismatch DNA repair and selective neuronal vulnerability in Huntington's disease remained unknown. The new study from UCLA Health and Jane and Terry ...

If DNA damage is not properly repaired, mutations can occur, which may result in diseases like cancer. Cells use repair systems to fix this damage, with specialized proteins locating and binding ...

This makes it important to study DNA repair in individual cells. Finding breaks in DNA is an enormous challenge. We don't know exactly where the damage occurs or why some areas are harder to repair.

Defects in the DNA mismatch repair machinery can be identified by detection of the loss of MMR protein expression with the use of immunohistochemical analysis or by detection of microsatellite ...

More information: Christopher J. Carnie et al, Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB, Nature Cell Biology (2024). DOI: 10.1038/s41556-024-01391-1 Journal ...