After decades of setbacks, Alzheimer’s drug development is expanding beyond anti-amyloids, with a record number of trials and ...

Tau protein is essential for microtubule stability and neuronal function. The protein’s disfunction is linked to several ...

Biological condensates are involved in several essential processes but may also be tangled into disease progression in protein misfolding diseases such as Alzheimer’s disease and tauopathies. One ...

Protein–protein interactions are no longer considered undruggable because of the conceptual and technical advances that allow inhibitors to be generated using rational design principles and ...

Here, we describe the tumorigenic involvement of ubiquitin protein ligase E3 component n-recognin 4 (UBR4), an E3 ubiquitin ligase of the N-degron pathway, in lung adenocarcinoma (LUAD). Public genome ...