After decades of setbacks, Alzheimer’s drug development is expanding beyond anti-amyloids, with a record number of trials and ...

Tau protein is essential for microtubule stability and neuronal function. The protein’s disfunction is linked to several ...

Lemborexant, a medication commonly used to treat insomnia, may help protect the brain from tau buildup, a marker of Alzheimer's progression, a mouse study suggests.

A harmful form of the tau protein, which builds up in Alzheimer's disease and similar brain disorders, can directly damage blood vessels in the brain, according to a new study by researchers at ...

About BIIB080 BIIB080 is an investigational antisense oligonucleotide (ASO) therapy designed to target microtubule-associated protein tau (MAPT) mRNA to reduce the production of tau protein.

Using a novel quantitative chemoproteomic strategy, the team uncovered a protective role of dopamine (DA) in regulating the function of the microtubule-associated protein Tau.

How to clear the toxic tau protein that can lead to Alzheimer's and related diseases Date: March 5, 2025 Source: Keck School of Medicine of USC Summary: The neurotransmitter glutamate is essential ...

They demonstrate convincingly using both immunohistochemistry in larval motor neurons and microtubule binding assays that Pfdn5 is a bona fide microtubule-associated protein contributing to the ...