Lecanemab presentations to include long-term Clarity AD data, real-world treatment insights, and a subcutaneous formulation ...

Scientists at Northwestern University and University of California, Santa Barbara have created the first synthetic fragment of tau protein that acts like a prion.

Clinical trials to test vaccine against Alzheimer's-promoting tau protein Date: April 23, 2025 Source: University of New Mexico Health Sciences Center Summary: Researchers hope to launch human ...

About BIIB080 BIIB080 is an investigational antisense oligonucleotide (ASO) therapy designed to target microtubule-associated protein tau (MAPT) mRNA to reduce the production of tau protein.

Using a novel quantitative chemoproteomic strategy, the team uncovered a protective role of dopamine (DA) in regulating the function of the microtubule-associated protein Tau.

When under stress, neurons crank out tau fragments, and many scientists blame this for the propagation of tangle pathology in Alzheimer’s disease. The fragments also directly compromise synapses they ...

They demonstrate convincingly using both immunohistochemistry in larval motor neurons and microtubule binding assays that Pfdn5 is a bona fide microtubule-associated protein contributing to the ...

Oxidative stress is an important driver of aging and has been linked to numerous neurodegenerative disorders, including Alzheimer’s disease. A key pathological hallmark of Alzheimer’s are filamentous ...