How one of the oldest components of the human immune system can trigger a mysterious and little-understood syndrome.

(100%) in the 180mg cohort achieved a clinical response Tryptase levels below the lower limit of quantification observed in ...

State‑of‑the‑art recommendations for clinician use and interpretation of mast cell tryptase tests were delineated in a review recently published online in Annals of Allergy, Asthma & Immunology.

Systemic mastocytosis is a rare disorder causing excessive mast cell buildup in organs. Learn about symptoms, types, causes, diagnosis, and treatments that improve life expectancy.

Mast cell activation syndrome, a disorder involving immune cells gone awry, ... Laboratory testing may include serum tryptase, histamine, prostaglandin D2, ...

Briquilimab targets c-Kit to address mast cell diseases. Patients saw substantial reductions in tryptase as early as week 1. 100% of patients with a single 240 mg dose had complete response at week 8.

--Blueprint Medicines Corporation today provided a 2025 corporate outlook and strategy for continued growth leveraging the company's proven R&D and commercial capabilities. We have a number of ...

Ultimately, her research led to mast cell activation syndrome, or MCAS, a condition in which mast cells ... your blood tryptase test should show a spike of 20% above your baseline, ...

Overall, I believe Briquilimab’s mechanism of action targeting mast cell survival via c-Kit blockage, provides Jasper with an opportunity to tap into blockbuster-potential markets (i.e., chronic ...

The involvement of mast cells (MCs) is documented by biochemical studies, preferably an increase in serum tryptase levels from the individual's baseline to plus 20% + 2 ng/mL.

Jasper saw fast, steep reductions in serum tryptase, a mast cell biomarker. However, tryptase levels were only stable for around four weeks. After that, levels of the biomarker began to rise and ...