This is a well-written study that presents a solid genetic screen to identify regulators of adipose morphology and remodeling in zebrafish. The authors generated a rigorous screening platform based on ...

Abstract Summary Pharmacological enhancement of endoplasmic reticulum (ER) proteostasis is an attractive strategy to mitigate pathology linked to etiologically-diverse protein misfolding diseases.

CHICAGO — A single infusion of zimislecel, an investigational stem cell-based therapy, restored physiologic islet function and conferred improved outcomes and insulin independence at 1 year ...

According to a phase 1 trial, the experimental HIVconsvX vaccine is safe and immunogenic among sub-Saharan African participants who bear the highest burden of HIV-1.

Discover 8 ways mast cell activation syndrome causes widespread symptoms from digestive issues to brain fog, often mistaken for other conditions.

A first-of-its-kind stem cell transplant has changed the life of a man who was left blind in one eye following a firework accident.

It’s rare for medical research to be truly ‘groundbreaking’, but the case study from China showing that stem cell therapy can reverse type 1 diabetes is worthy of this adjective.

Mast cell activation syndrome (MCAS) is a condition where the mast cells are inappropriately triggered.

Thus, a nociceptor-mast cell axis plays a crucial role in sensing cysteine protease activity and initiating Th2 cell-driven responses in the skin. However, the specific receptors in TRPV1 + sensory ...

Introduction: Mouse mast cell protease-4 (mMCP4) is a chymase that has been implicated in cardiovascular diseases, including myocardial infarction (MI). Here we tested a direct role of mMCP4 in mouse ...