Kounis syndrome is the concurrence of acute coronary syndromes with conditions associated with mast cell activation ... IgE-mediated diseases (Box 1). Despite cardiovascular symptoms and signs ...

The values for submucosal eosinophil counts, mast-cell counts, and thickness of the basement membrane and lamina reticularis are presented in Figure 1. The median submucosal eosinophil count was 2 ...

such as PD-1 and Siglec-10, have demonstrated therapeutic activity in immunology and oncology. AK006 appears to drive deep mast cell inhibition and, in addition to its inhibitory activity ...

8 Mast cells can be activated by several stimuli acting on numerous cell surface receptors. The responses to different stimuli are influenced by a multitude of factors that affect the surface ...

Bone-marrow mast-cell counts were correlated with the level of bone density. Fifty-three patients were considered to have normal or only a slight reduction in bone density (Group 1). Thirty-seven ...

In the CSU cohort, approximately 60 adult patients with antihistamine refractory CSU (including patients with prior biologics treatment), will be randomized 2:1 to receive 720 mg of IV AK006 or ...

EP262 is a first-in-class, potent, highly selective small molecule antagonist of MRGPRX2, a receptor mediating non-IgE driven mast cell degranulation ... conduct a Phase 1 study in the first ...

Dr. Jim Harris from the South Bend Clinic and one of his patients, Michelle Rannells, joined us on 16 News Now at Noon to talk about mast cell disease. Dr Harris says it’s prevalent in women and ...