In phase 1, 75% of patients had also received chemotherapy whereas only 31% had in phase 2. In the phase 1 portion of the trial, ARV-110 doses ranged from 35–700 mg QD or 210–420 mg BID. Based on ...

As of February 28, 2025, 99 patients were enrolled (Phase 1a, n=8; Phase 1b, n=6, Phase 2, n=30, 25, and 30 in Cohorts A, B, and C, respectively). The baseline characteristics are summarized below: ...

Ateganosine (THIO, 6-thio-dG or 6-thio-2’-deoxyguanosine) is a first-in-class investigational telomere-targeting agent currently in clinical development to evaluate its activity in non-small ...

2:02 Phase 2 of Valley Line West LRT road closures begin. The City of Edmonton is moving into the next phase of its accelerated roadwork this summer to make room for the Valley Line West LRT.

Southern California air regulators reject rules to phase out gas furnaces and water heaters. Southern California air regulators reject rules to phase out gas furnaces and water heaters. 1 of 2 | A ...

CMRL will upgrade Chennai’s public transport network by introducing its first driverless metro train by February 2027. As part of Chennai Metro Rail Limited’s (CMRL) Phase-2 expansion, this ...

TXDOT says this closure is partly due to phase 2 of the $53 million project to extend the I-69 Brazos River Bridge and the feeder lanes north by 1,000 feet.

As phase-1 of Fairhope’s Fly Creek Nature Preserve nears completion, planners address concerns over phase-2. Phase one of Fly Creek Nature Preserve will soon open to the public.

Telangana Cabinet clears Hyderabad Metro Phase 2B expansion, DA hike and ₹33,000 crore for road development Kothagudem Earth Sciences University named after former Prime Minister Manmohan Singh.

Voting for the 2025 MLB All-Star Game began on Wednesday, June 4th at 12 p.m. ET. Check out everything you need to know about voting this year, including dates, how it works and results. Phase 1 ...

Earlier Phase 1 studies in healthy volunteers had shown a dose-dependent reduction in lymphocyte count—considered a surrogate marker for this class of compounds. Despite no major safety issues ...

Sun Pharma Advanced Research Company (SPARC) psoriasis drug, Vibozilimod (SCD-044), failed to meet primary endpoints in Phase 2 trials for psoriasis and atopic dermatitis. The company has decided to ...