Wag31 levels influence lipid homeostasis. Next, we set out to analyze if the ILIs are indeed lipidic in nature by staining cells with BODIPY (493/503), a dye that preferentially partitions into ...

Thanks to an unusually complex molecular structure, this protein can deplete a metabolite essential for cellular function. Left without fuel, the viral invader's plans for a further onslaught are ...

Bayer announced today initiation of a Phase I clinical trial with 225Ac-GPC3 (BAY 3547926), an investigational targeted alpha radiopharmaceutical being devel ...

One of the challenges of traditional protein-based immunization is the production of full-length MP immunogens in their native, membrane-associated form using recombinant protein techniques. The ...

SQSTM1, or P62, is a multifunctional protein that plays a vital role in immunity and cellular autophagy.SQSTM1/P62 was initially identified as an autophagy junction consisting of the PB1/TRAF6 binding ...

Figure 1: The Membrane Mimetic-Thermal Proteome Profiling (MM-TPP) experimental workflow. 1) Crude membranes are prepared from the liver organ.2) Integral membrane proteins (IMPs) are solubilized with ...

Last week, US food manufacturer Conagra Brands set out plans to affix labels on some of its Healthy Choice products in the new year in a bid to catch the eye of users of GLP-1 drugs.. The “On Track” ...

In 2024, new studies have exposed additional layers of this story, showing, for example, that along with bacteria and eukaryotic cells, archaea also exchange vesicle-bound RNA, which confirms that the ...

And those internal controls, in turn, affect the cellular membrane, which allows these unassuming blobs to affect global traits and outcomes such as resistance to antibiotics. Biological condensates ...

Aging is a major risk factor for neurodegenerative diseases, but the molecular mechanisms behind this relationship are not clear. In a recent study, researchers explored the role of PQBP3, a ...