Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...

(C) PFS and (D) OS in class 2 versus other MAP2K1 mutant tumors in patients treated with MEK inhibitor–containing treatment regimens. (E) PFS and (F) OS in patients who experienced a response to MAPK ...

Mitogen-Activated Protein Kinase (MAPK) signaling pathways play a crucial role in various cellular processes, including growth, differentiation, and response to stress. These pathways are ...

The secretion of IL-6 was monitored by ELISA in cell culture supernatants from conventional cultured FLS treated with NaHS or MAPK inhibitors ... 1/2 (68 ± 16% and 90 ± 27%), mitogen- and stress ...

We further analyze the tumor characteristics that result in the development of intrinsic or inherited resistance to BCL-2 inhibitors ... In response to several cytotoxic stimuli, such as developmental ...

Several melanoma cell lines were exposed to inhibitors of Src activity despite ... of melanoma cells through activation of the RAF/MEK/MAPK pathway [4]. Despite the impressive initial responses, ...

However, these artificial circulation systems in general have been associated with activation of the inflammatory and oxidative stress responses in patients and ... (e.g.' using heparin or direct ...

Previous research has indicated that MAPK inhibitors could be a potential therapy for NRASMUT melanoma. However, on their own, MAPK inhibitors fail in about 80% of cases and don’t extend patient ...

Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...