Diverse FLNC heterozygous variants including those that cause haploinsufficiency and those that cause FLNC misfolding impair the turnover of Z-disc proteins, activate autophagy, and increase lysosome ...

Autophagy plays a crucial role in cell homeostasis by controlling intracellular clearance and recycling of a variety of molecules and cellular components and also by sustaining cellular energy ...

Autophagy, a cellular mechanism responsible for maintaining cellular equilibrium by removing dysfunctional organelles and misfolded proteins, plays a vital role in cell health and is implicated in ...

Sonodynamic therapy (SDT) is a promising noninvasive cancer treatment due to its superior tissue penetration depth compared to phototherapy. Herein, we developed a lysosome-targeted cyclometalated ...

Many autophagy-related proteins are regarded as prognostic markers of RCC. Researchers have attempted to explore synthetic and phytochemical drugs for RCC therapy that target autophagy. In this review ...

Andrea Ballabio, founder of TIGEM, has received the 2025 Beth Levine Prize for his pioneering research on lysosomes and autophagy. His work, largely conducted at TIGEM, has led to new insights ...

Dysfunction of the autophagy–lysosome pathway has been implicated in a variety of neurodegenerative diseases, including Alzheimer’s disease, highlighting the value of new strategies for therapeutic ...