New research shows that older adults may compensate for age-related cognitive decline by enhancing activity in a specific ...

To varying degrees, this decreased the firing of locus coeruleus neurons and reduced their release of norepinephrine. “The peri-LC cells apparently act like a radio gain circuit that can dial up or ...

The analysis showed that, like the locus coeruleus, the peri-LC neurons receive inputs from major centers of the brain and spinal cord but transmit signals almost exclusively to the locus coeruleus.

“By examining the health of the locus coeruleus and its relation to cognitive aging processes, these data may reveal when an individual is on a healthy aging trajectory and advance our ...

The locus coeruleus lies in the brain stem, just above the back of the neck – and contains around 50,000 cells, a tiny portion of the 86 billion neurons in the average central nervous system.

The locus coeruleus (LC) produces catecholamines norepinephrine and dopamine. Our group has investigated the extent to which the PET tracer [18 F]Fluoro-m-tyrosine (FMT) can be used to assess the ...

However, there is still much to learn about brain activity during flow states. Scientists continue to debate how different parts of the brain interact to produce this state. More recent experiments ...

Locus coeruleus (LC) projections to the hippocampus play a critical role in learning and memory. However, the precise timing of LC-hippocampus communication during learning and which LC-derived ...

Norepinephrine neurons in the locus coeruleus regulate heartbeat, blood pressure, arousal, memory, attention and “fight or flight” reactions. Humans have approximately 50,000 LC-NE neurons in ...

Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells. Nature Biotechnology, 2023; DOI: 10.1038/s41587-023-01977-4 ...