A study has identified a key disruption in cholesterol transport to the brain in patients with Alzheimer's disease. The ...

BACKGROUND: Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease with no effective pharmacological treatments. The causal role of triglycerides (TGs) in AAA development remains ...

Daily doses of obicetrapib over 52 weeks led to significant reductions in plasma p-tau217 and other Alzheimer’s disease ...

Integrating novel multi-ancestry PRS methods (e.g., PROSPER/PRS-CSx) with GWAS across ancestries enhances prediction accuracy for AD risk among Hispanic population. APOE and PRS may point to different ...

Find insight on O’Reilly Automotive, American Airlines, Southwest Airlines and more in the latest Market Talks covering Auto and Transport.

Meet 12 biotech companies with promising genetic disease therapies that successfully closed funding rounds recently.

The origins of the seed membranes and their relationship to the lipid transport machinery are poorly understood. Using proximity labeling and a variety of fluorescence microscopy techniques, we show ...

This signature reveals a fundamental, disease-independent vulnerability linked to APOE ε4, reframing our understanding of genetic risk in conditions like Alzheimer's, Parkinson’s, ALS, and FTD.

We identified Apoe as a critical protective gene that is downregulated in low-temperature conditions. The reduction in APOE levels correlates with increased lipid accumulation in cartilage, leading to ...