Cholesterol is an important part of your body’s health, but too much of the wrong kind can lead to serious problems like ...

Successive enzymatic reactions by a number of enzymes are generally required to achieve a single biologically active compound. Biosynthesis can be exploited for chemical synthesis in vitro or in ...

Mirum Pharmaceuticals' Ctexli wins FDA approval for CTX, a rare lipid storage disease. The company projects 2025 global sales of $420–$435 million.

Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and antioxidant defenses, plays a central role ...

The concept of using vaccines to treat cancers has been around for several decades. A vaccine was first approved for prostate cancer in 2010, and another was approved in 2015 for melanoma. Since then, ...

A breakthrough study has uncovered a hidden player in Parkinson’s disease—24-OHC, a cholesterol metabolite that fuels the ...

Oxysterols are a class of molecules derived from cholesterol via oxidation or as byproducts of cholesterol synthesis. Despite ...

Free radicals are produced in the body during normal cellular metabolic activities, and their excessive accumulation can overwhelm the natural antioxidant mechanisms. This leads to oxidative stress, ...

Researchers suggest drugs that prevent cholesterol from being converted to 24-OHC might therefore be an effective treatment for Parkinson's disease.

Chinese scientists say preventing cholesterol from being converted to 24-OHC might be an effective treatment for Parkinson's ...

When a tumour develops, it creates a structure around itself called the tumour stroma, within which blood and lymphatic vessels ensure nutritional and respiratory biological exchanges.