Neurodegenerative diseases (NDs) are generally considered proteinopathies but whereas this may initiate disease in familial cases, onset in sporadic diseases may originate from a gradually disrupted ...

3.2 Increased microgliosis and Aβ 42 accumulation were observed in the hippocampus of ApoE4 KI mice. Microgliosis and Aβ 42 accumulation in the hippocampus have been considered a hallmark of AD ...