Topline results were announced from a phase 3 trial evaluating valiltramiprosate (ALZ-801) in apolipoprotein ε4 allele (APOE4) carriers with early Alzheimer disease (AD). Valiltramiprosate is an ...

That's what's at work with research into the APOE4 gene. According to a recent study released by the National Institutes of Health and published in "Nature Medicine," the disease may be more ...

and Lynn Scaduto Mind Institute at Miami Jewish Health in Florida. But not everyone with two copies of APOE4 had other clinical symptoms, which usually are the trigger for an Alzheimer’s ...

In this new study, the research team has found evidence suggesting that AD due to homozygous APOE4 genes should be classified as a third general type of the disease, rather than as a risk factor.

For 30 years, APOE4 has ranked as the strongest genetic risk factor for Alzheimer’s disease, with two copies boosting the odds up to 15-fold. Now, scientists argue that people with two APOE4 alleles ...

What do the findings mean for your Alzheimer’s risk, and should you get tested for the APOE4 gene? Here are answers from neurologists Ayesha Sherzai, MD, and Dean Sherzai, MD, PhD, the co-direct ...

This means the APOE4 gene may no longer merely a risk factor but the driver behind a new stand-alone genetic Alzheimer's disease type that could impact up to 10 million Americans and more than 200 ...

An MRI of a brain of a person with Alzheimer's disease. A new study suggests having two copies of a genetic variant called APOE4 is a cause of the disease, not just a risk factor for it.

APOE3 is thought to confer a neutral risk of the disease. APOE4, on the other hand, is bad news. It has long been recognized that people with at least one copy of the APOE4 gene have an elevated ...

Scientists have long known a gene called APOE4 is one of many things that can increase people’s risk for Alzheimer's, including simply getting older. The vast majority of Alzheimer’s cases ...

For more than 30 years, Alzheimer’s researchers have thought of APOE4 as a major genetic risk factor for most cases of the devastating neurologic disease. But a new study published on Monday ...

People with two copies of the gene variant APOE4 are almost certain to get Alzheimer’s, say researchers, who proposed a framework under which such patients could be diagnosed years before symptoms.