Iran has launched a new wave of missile attacks on Israel, triggering air raid sirens across the country as emergency services reported at least five killed and dozens more wounded in the fourth day of open warfare between the regional foes.

Iran announced it had launched some 100 missiles and vowed further retaliation for sweeping attacks on its military and nuclear infrastructure.

Iran fired a new wave of missile attacks on Israel early Monday, killing at least five people, while Israel claimed in the fourth day of the conflict that it had now achieved “aerial superiority” over Tehran and could fly over the Iranian capital with impunity.

An Israeli strike hit Iran's state broadcaster on Monday while the head of the U.N. nuclear watchdog indicated extensive damage to Iran's biggest uranium enrichment plant and Iran called on the U.S. to force a ceasefire in the aerial war.

Israel unleashed airstrikes across Iran for a third day Sunday and threatened even greater force as some Iranian missiles evaded Israeli air defenses to strike buildings in the heart of the country. Planned talks on Iran’s nuclear program,