Thrombin, in turn, facilitates the activation of the intrinsic pathway, causing an increase in thrombin generation in an amplification loop. [28, 30, 31] The presence of platelets increases ...

The process of forming a blood clot is called coagulation. Coagulation is a key player in the repair and maintenance of the circulatory system. However, in some cases, such as major surgery, there is ...

FXI-ASO, under development by Isis, is an antisense oligonucleotide that reduces the level of factor XI, a key component of the intrinsic (contact) coagulation pathway.

Michael P. Gulseth Disclosures Am J Health Syst Pharm. 2005;62 (4):1451-1467.

The clotting cascade of human blood plasma follows two prominent pathways; intrinsic, measured by Activated Partial Thromboplastin Time (aPTT) and extrinsic, measured by Prothrombin Time (PT).

Specifically, they showed that the "extrinsic" blood clotting pathway is critical for protective clotting during sepsis whereas the "intrinsic" pathway appears to be dispensable.

The various coagulation tests used to detect lupus anticoagulant activity are indicated in italics, and the figure shows a simplified schematic diagram of the coagulation pathway evaluated by each ...

Hemostasis is accomplished through a network of processes that include the platelet system, coagulation, and anticoagulant and fibrinolytic pathways, which all support the dynamic equilibrium that ...