Here we show that prolonged (∼30 min) exposure of ORL1 receptors to their agonist nociceptin triggers an internalization of these signaling complexes into vesicular compartments. This effect is ...

Merlin' serves as a gatekeeper in new blood vessel formation. Merlin suppresses internalization of VEGFR2, which is important for the formation of 'tip' endothelial cells. Blood vessels are the ...

These bispecific constructs have demonstrated the potential to overcome drug resistance, increase internalization rates, and improve the safety profile of ADCs. The mechanism of action of ...