Disclosure: Dr. Sebba has received financial support in the form of research grants and lecture honoraria from Hoffmann-La Roche Inc. Cells producing interleukin-6 (IL-6) and the actions of IL-6 ...

However, durable remission rate with checkpoint inhibitor ... to IL-6 and Th17 cells identified here, targets identified in other studies include tumor necrosis factor. Interleukin-1-beta, myeloid ...

Induction therapy with a novel interleukin 6 (IL-6) inhibitor for active ulcerative colitis yielded significantly higher rates of clinical response, remission, and mucosal healing than placebo ...

The combination of an IL-6 blocker with immune checkpoint inhibitor decreased experimental ... More information: Adi Diab, Interleukin-6 blockade abrogates immunotherapy toxicity and promotes ...

Your doctor has recommended expanding your treatment plan for rheumatoid arthritis (RA) to include an interleukin 6 (IL-6) inhibitor — a biologic that’s often prescribed when conventional ...

This mechanism is distinct, but complementary to, a previously described suppression mechanism involving interleukin ... IL-6 acts to upregulate SOCS3, the Suppression of Cytokine Signaling 3 protein, ...

Anti-interleukin-6 receptor monoclonal antibody ... Contrastingly, among IL-6 inhibitor recipients, male patients showed a lower risk of pulmonary respiratory failure and death than their female ...

The efficacy and safety of upadacitinib — a selective Janus kinase (JAK) inhibitor that blocks the signaling of several cytokines, including interleukin-6 and interferon-γ — are unknown in ...

Summary: Tocilizumab is a novel monoclonal antibody that competitively inhibits the binding of interleukin-6 (IL-6 ... a novel IL-6R inhibitor, may be beneficial for the treatment of RA in ...

Researchers have identified a novel strategy to reduce immune-related adverse events from immunotherapy treatment by targeting the cytokine interleukin ... 6 blocker with immune checkpoint ...