News

Ozempic in a pill? The next generation of weight-loss drugs emerges
Rochelle McDonald has just been through the messiest of break-ups. “Guzman y Gomez were devastated,” she says, but 17 kilos ...
insideHPC1d
Livermore Lab: Cancer Drug Candidate Developed Using HPC and AI Blocks Tumor Growth
A new cancer drug candidate developed by Lawrence Livermore National Laboratory, BridgeBio Oncology Therapeutics and ...
Mirage News2d
AI-Powered Cancer Drug Halts Tumors, No Toxic Effects
A new cancer drug candidate developed by Lawrence Livermore National Laboratory (LLNL), BBOT (BridgeBio Oncology Therapeutics ...
C&EN2d
Synthesis, Structure–Activity Relationships and Brain Uptake of a Novel Series of Benzopyran Inhibitors of Insulin-Regulated Aminopeptidase
Peptide inhibitors of insulin-regulated aminopeptidase (IRAP) enhance fear avoidance and spatial memory and accelerate spatial learning in a number of memory paradigms. Using a virtual screening ...
eLife3d
Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD
This is a useful study in the role of CHI3L1 in Kupffer cells, the macrophages of the liver, showing that CHI3L1 alters glucose regulation in obesity. Specifically, Chi3l1 protects glucose-dependent ...
Novo Nordisk's Cardiometabolic Foundation Supports Wide Moat
Strong efficacy and cardiovascular benefits should allow Novo to continue growing sales of GLP-1 therapies in diabetes. While Novo lost share to Eli Lilly's once-weekly Trulicity, Ozempic and Rybelsus ...
C&EN6d
Highly Stable Hexacoordinated Nonoxidovanadium(IV) Complexes of Sterically Constrained Ligands: Syntheses, Structure, and Study of Antiproliferative and Insulin Mimetic ...
Three highly stable, hexacoordinated nonoxidovanadium(IV), VIV(L)2, complexes (1–3) have been isolated and structurally characterized with tridentate aroylhydrazonates containing ONO donor atoms. All ...