This study offers useful findings demonstrating the cartilage-protective effects of osteoactivin in inflammatory experimental models. The study provides compelling evidence that osteoactivin may serve ...

Elevated IL-6; a proinflammatory cytokine, contributes to liver steatosis and pancreatic β-islet cells dysfunction. This study explores pancreatic tissue-resident (tr)NK cells IL-6 receptor (IL-6R) in ...

For IL-27p28 detection, mouse IL-27p28/IL-30 Quantikine ELISA kit (M2728; R&D Systems) was used according to the manufacturer’s protocol. Immunofluorescence of bone marrow and image analysis Procr ...

Inhibition of LXR in human foam cells has a proinflammatory effect on endothelial cells, partly due to increased IL-6 production.

IL-6 R protein docking The drug tocilizumab was developed to block IL-6 receptors in humans; however, our findings were obtained by conducting biological testing in animal models using Rattus ...

Significant advancements in chimeric antigen receptor (CAR) T-cell therapy have occurred over the past several years as successful clinical trials and FDA approvals have positively impacted patient ...

In active SLE, CRP levels are disproportionally low for increased IL-6 levels. While a molecular explanation is lacking, these low CRP levels have been found associated with increased type I ...

It is caused by pathological autoantibodies against components expressed at neuromuscular junctions, such as acetylcholine receptor (AChR). Interleukin-6 (IL-6) has been suggested to play a role in ...