A correlation between hepcidin expression and hepatic iron burden has also been found in humans. 16,22,23 IL-6 does not seem to be involved in the regulation of hepcidin in response to iron, as IL ...

The hepcidin-activating pathway is emerging as a target for treatments aimed at modulating the iron status. Hepcidin mimetics (minihepcidins) have shown promise in reducing iron overload in ...

Iron accumulation in the liver has a negative influence on chronic hepatitis C outcome. Hepcidin, a versatile regulator of iron homeostasis is engaged in this process. Nevertheless, factors ...

Hepcidin binds to the nonheme iron exporter ferroportin 1, induces its internalization and degradation, and is vital for maintaining iron homeostasis throughout the body. Hepcidin deficiency leads ...

Scientists find that differential expression of expression patterns in transplant patients predicts who will or won’t be able to tolerate weaning off immunosuppressive drugs.

A Quick Review. Iron is a trace mineral that supports growth, development, red blood cells, and hormone synthesis. While anemia is not a direct cause of weight gain, being overweight or obese can ...

Hepcidin, a liver-derived hormone, regulates iron homeostasis by inhibiting intestinal iron absorption and iron release from macrophages. In β-thalassemia, hepcidin levels are inappropriately low ...

Yook JS, Thomas SS, Toney AM, et al. Dietary iron deficiency modulates adipocyte iron homeostasis, adaptive thermogenesis, and obesity in C57BL/6 mice. J Nutr . 2021;151(10):2967-2975. doi:10.1093 ...

By Dr. Chinta Sidharthan New research highlights how elevated levels of the iron-regulating hormone hepcidin contribute to psoriasis by driving skin cell proliferation and inflammation, offering ...

Transmembrane serine protease 6 (TMPRSS6) is a negative regulator of hepcidin, which is the main iron homeostasis-regulating hormone. Regeneron Pharmaceuticals Inc. has recently presented preclinical ...