To this end, NMDP-sponsored phase 2 trial assessed human leukocyte antigen (HLA)-mismatched unrelated donor bone marrow transplantation with posttransplant cyclophosphamide.

HLA-DP antigens are beta-alpha heterodimers encoded by polymorphic HLA-DPB1 and -DPA1 alleles, respectively, in strong linkage disequilibrium (LD) with each other. Non-permissive unrelated donor ...

The importance of matching for HLA-DPB1 in unrelated donor haematopoietic stem cell (HSC) transplantation is little understood. Most transplant centres do not, currently, prospectively match for ...

An analysis of registry data from the United Network for Organ Sharing suggests that human leukocyte antigen matching, ¬compared to human leukocyte antigens non-matching results, is a ...

"HLA matching is the main way of risk stratifying when it comes to kidney transplant," said Cherukuri. "Even with a good HLA match, recipients must take immunosuppressant drugs for the rest of ...

Mehta, R. S., Petersdorf, E. W., Wang, T., Spellman, S. R., & Lee, S. J. (2024). Interplay between donor age and HLA-DP matching in 10/10 HLA-matched unrelated donor HCT. Blood Advances, bloodadvances ...

Correspondence HLA Matching for Hematopoietic Stem-Cell Transplants Published April 18, 2002 N Engl J Med 2002;346: 1251 - 1252 DOI: 10.1056/NEJM200204183461616 ...

Matching donors for stem cell transplantation demands both precision and speed, especially as requests for high-resolution human leukocyte antigen (HLA) data grow. As labs adapt to higher workloads ...

NMDP’s network of transplant centers, many of which participate in CIBMTR trials, are bringing new research to light that is challenging previously established stem cell transplantation science.

"HLA matching is the main way of risk stratifying when it comes to kidney transplant," said Cherukuri. "Even with a good HLA match, recipients must take immunosuppressant drugs for the rest of ...