HIV-1 protease inhibitors (PIs) have long been central to antiretroviral therapy, directly targeting the enzyme responsible for processing viral polyproteins into functional units.

The first generation of HAART controlled HIV’s protease and reverse transcriptase — essentially tying both of the virus’ hands behind its back. Newer antiretrovirals combine reverse transcriptase ...

HIV treatment includes multiple drugs. If you’re taking a protease inhibitor for your HIV, a booster drug will help it work better. Learn more about how it works and what to watch for.

Between May 1, 2020, and May 31, 2021, they enrolled 169 people with HIV who were been treated with ART with PI, and 338 patients with HIV taking ART without PI.

Hepatitis C was discovered in 1989. It took 22 years for these two – the first antiviral drugs to cure the infection – to be discovered and developed. (4) Invirase (1995) was the first HIV protease ...

HIV protease inhibitors turn them up and turn them down at the same time. To put that all together and tell a healthcare provider what to do, it turns out, is often quite complex.

Drs Michael S. Saag and Rajesh Gandhi discuss HIV and antiretroviral therapy guidelines -- when to begin treatment, which treatment to choose, and how to treat the whole person, not just the HIV.

(Left) An example of lipodystrophy caused by protease inhibitors. Source: Aesthetic Surgery Journal. (Right) Daily pill burden, then and now. Source: Gilead Biosciences A massive effort By the late ...

A supercharged HIV vaccine could offer strong protection with just one injection, a study in mice has indicated. Developed by researchers from the Massachusetts Institute of Technology (MIT) and ...

Social media users have questioned why a treatment approved to treat COVID-19 contains an HIV protease inhibitor. It comes after the United States authorised Pfizer's antiviral Paxlovid as the ...

Gilead Sciences Inc. recently disclosed details on the work that led to the discovery of elunonavir (GS-1156), an unboosted HIV protease inhibitor currently in phase I studies.