Excessive signaling by G protein-coupled receptors (GPCRs) contributes to various human disorders, necessitating novel therapeutic strategies. Here, the authors identify a small molecule that ...

G protein–coupled receptors (GPCRs) constitute an abundant family of membrane receptors of high pharmacological interest. Cell-based assays are the predominant means of assessing GPCR activation ...

We mapped an autosomal recessive form of this disorder to chromosome 13q14.11–13q21.33, and identified homozygous truncating mutations in P2RY5, which encodes an orphan G protein–coupled receptor.

A new method for analyzing membrane protein oligomerization by bioluminescence resonance energy transfer (BRET) suggests that dimerization of G protein–coupled receptors (GPCRs) may not be as ...

G protein-coupled receptors (GPCRs), crucial for diverse physiological responses, have traditionally been investigated in their monomeric form. However, some GPCRs can form heteromers, revealing ...

Dublin, May 06, 2025 (GLOBE NEWSWIRE) -- The "G-Protein Coupled Receptor (GPCR) Targeting: Technologies and Global Markets" report has been added to ResearchAndMarkets.com's offering.The global G ...

Allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain. Compuscript Ltd. DOI 10.1016/j.apsb.2023.07.020 ...