Excessive signaling by G protein-coupled receptors (GPCRs) contributes to various human disorders, necessitating novel therapeutic strategies. Here, the authors identify a small molecule that ...

G protein–coupled receptors (GPCRs) constitute an abundant family of membrane receptors of high pharmacological interest. Cell-based assays are the predominant means of assessing GPCR activation ...

G protein-coupled receptors (GPCRs), crucial for diverse physiological responses, have traditionally been investigated in their monomeric form. However, some GPCRs can form heteromers, revealing ...

Dublin, May 06, 2025 (GLOBE NEWSWIRE) -- The "G-Protein Coupled Receptor (GPCR) Targeting: Technologies and Global Markets" report has been added to ResearchAndMarkets.com's offering.The global G ...

A new method for analyzing membrane protein oligomerization by bioluminescence resonance energy transfer (BRET) suggests that dimerization of G protein–coupled receptors (GPCRs) may not be as ...

Allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain. Compuscript Ltd. DOI 10.1016/j.apsb.2023.07.020 ...

Singer Karol G is calling out GQ Mexico magazine over the image of her on their most recent cover, which she says does not accurately depict her face or body. On April 6, GQ Mexico published its ...

Many peptide hormones elicit a wide array of physiological effects by binding to G-protein coupled receptors. We have determined the conformation of pituitary adenylate cyclase activating ...

The G-protein-coupled P2Y2 receptor (P2Y2-R) is abundantly expressed on the airway lumenal surface and internalizes into coated pits upon agonist activation.