A single low dose injection of esketamine given immediately after childbirth reduces major depressive episodes in individuals with depressive symptoms during pregnancy (prenatal depression), finds ...

The researchers found a 74% reduction in the risk for postpartum depression in the group that received esketamine (6.7% vs 25.4%). Depression scores on the Edinburgh Postnatal Depression ...

In 2023, esketamine showed superiority to quetiapine when it exhibited a 54% increased likelihood of patients reaching remission for treatment-resistant depression (TRD) at 8 weeks. 2 TRD affects ...

Esketamine is J&J's patented version of ketamine, a dissociative anesthetic with psychedelic properties that was first synthesized in 1962. Numerous scientific studies have demonstrated ketamine's ...

Budapest, Hungary — A single dose of intravenous esketamine during delivery or caesarean section appears to reduce the risk for postpartum depression (PPD) by more than 50% in the first 6 weeks ...

Esketamine administered intravenously during elective cesarean delivery may significantly reduce depressive symptoms in the early postpartum period, according to study results published in JAMA ...

More information: Antonio Del Casale et al, Esketamine Combined With SSRI or SNRI for Treatment-Resistant Depression, JAMA Psychiatry (2025). DOI: 10.1001/jamapsychiatry.2025.0200 Journal ...

New hope for treatment-resistant depression. Understanding what emotional intelligence looks like and the steps needed to improve it could light a path to a more emotionally adept world.

However, esketamine NS is the only specifically approved therapy for treatment-resistant depression in Europe (it is also given alongside other antidepressants). Esketamine NS is a nasal spray ...

Esketamine plus SNRI cohort showed better survival probability than esketamine pls SSRI group. Credit: JAMA Psychiatry (2025). DOI: 10.1001/jamapsychiatry.2025.0200 ...

Ketamine has a long and varied past as a pharmaceutical. It was developed in 1962, tested on subjects in 1964 and approved as an anesthetic in 1970 in the United States. Ketamine was used in the ...