The presence of endotoxin in sterile pharmaceutical products presents a significant risk to patients, and this includes vaccines. During preclinical development of the next generation vaccines ...

Chain reaction Endotoxin tests rely on factor C, a lipopolysaccharide-sensing protease found in horseshoe crab blood. When activated, factor C cleaves and activates another protease.

As thoroughly covered in your recent article (C&EN, Oct. 28, 2024, page 26), the issue of replacing the traditional natural product test for endotoxin, limulus amoebocyte lysate (LAL), with a ...

Objective: Endotoxin, a component of the outer membrane of gram-negative bacteria, elicits a strong innate and inflammatory immune response associated with the secretion of proinflammatory cytokines, ...

Recent studies have highlighted the presence of endotoxin in indoor air and its role in respiratory morbidities. Burning of household fuels including unprocessed wood and dried animal dung could ...

Have you ever wondered why endotoxin testing is crucial? Endotoxins are toxic substances found in the outer membrane of Gram-negative bacteria, and they can cause severe reactions in humans, including ...

M. tuberculosis, which kills more than 1 million people a year, uses the ESX-4 type VII secretion system to transports its potent exotoxin. Six years ago, Michael Niederweis, Ph.D., described the ...

Laurent Castellucci February 10, 2003 Mon, 10 Feb 2003 22:30:00 ...

Stick this in your pipe — er, vape — and smoke it. Harvard researchers have found that popular electronic cigarette brands are contaminated with bacterial and fungal toxins. “In addition to i… ...

Exotoxin A is an extracellular enzyme that is produced by most clinical strains of Pseudomonas aeruginosa. It is a single-chain polypeptide (molecular weight, 71,000) with A and B fragments that ...

2. Kass, E. H. Effect of corticosteroids and of hormones of pregnancy on lethal action of bacterial endotoxin. Ann. New York Acad. Sc. 88:107–115, 1960.