Tweaking the spacing between binding domains on the ECM surrounding cancer cells can boost their killing via ultrasound ...

Cell migration affects all morphogenetic processes and contributes to numerous diseases, including cancer and cardiovascular disease. Cell migration begins with protrusion of the cell membrane ...

Laboratory for Research on the Structure of Matter (LRSM), University of Pennsylvania, Philadelphia, United States ...

Cells have surface receptors called integrins that bind to repetitive domains present on the extracellular matrix (ECM) surrounding the cells, allowing them to grow and spread. A new study from the ...

Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...

Focal adhesions (FAs) are structures that connect cells to the extracellular matrix (ECM) (the cell's external ... through the promotion of focal adhesion maturation. This gene was pinpointed ...

This study aims to characterise ECM components of the stem cell niche in ... by low-density plating and differential adhesion to plastic and fibronectin substrates. Cells were analysed by flow ...

It outperformed the other samples in cell adhesion, proliferation, osteogenic gene expression, collagen production, ALP activity, and ECM mineralization. Sr release from PEEK-Sr10 sustained ...