El Macho El Macho is the villain of Despicable Me 2. In the film, he joins forces with Dr. Nefario in order to kidnap and mutate Gru’s minions with the help of the PX-41 formula.

Mutated Minions These Minions Were Injected With The PX-41 Chemical In Despicable Me 2, another iteration of minions is seen, often called the " purple " or " mutated " minions.