Research reveals that δ-receptor agonists like KNT-127 alleviate IBS symptoms by modulating gut-brain interactions and reducing stress-induced hypermotility.

The delta opioid receptor (DOP) plays a key role in mood regulation, making it a promising target for therapeutic intervention. Studies have shown that selective DOP agonists (compounds that ...

Irritable bowel syndrome (IBS) is a common digestive disorder with unclear causes, affecting about 10% of the global population. Researchers from Japan have now discovered that opioid delta-receptor ...

Using an innovative and recently validated animal model of IBS, the researchers showed that opioid delta-receptor agonists ...

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A groundbreaking study suggests that IBS might be more of a brain issue than a gut disorder. Researchers found that ...

Opioid use during pregnancy—whether of highly addictive drugs like fentanyl or controlled opioids like buprenorphine—doubles ...

They found that a gene called Oprl1 (opioid receptor-like 1), which encodes the receptor for an opioid called nociceptin, is more active in mice subjected to extreme stress than in controls. Ressler ...

A Jacobs School of Medicine and Biomedical Sciences researcher has received National Institutes of Health funding to gain better understanding of the neural mechanisms underpinning drug-mediated ...

Researchers have now discovered that opioid delta-receptor agonists may alleviate IBS symptoms by acting directly on the central nervous system. Using a novel stress-induced mouse model ...